assignリスト内包表記とともに使用して、score辞書から値のタプル(各行)を取得し、見つからない場合はデフォルトでゼロになります。
>>> df.assign(score=[score.get(tuple(row), 0) for row in df.values])
   gender  age  cholesterol  smoke  score
0       1   13            1      0      0
1       1   45            2      0      0
2       0    1            2      1      5
3       1   45            1      1      4
4       1   15            1      7      0
5       0   16            1      8      0
6       0   16            1      3      0
7       0   16            1      4      0
8       1   15            1      4      0
9       0   15            1      2      0
タイミング
さまざまなアプローチを考えると、いくつかのタイミングを比較することは興味深いことですが。
# Initial dataframe 100k rows (10 rows of identical data replicated 10k times).
df = pd.DataFrame(data = {
    'gender' :      [1,  1,  0, 1,  1,  0,  0,  0,  1,  0] * 10000,
    'age' :         [13, 45, 1, 45, 15, 16, 16, 16, 15, 15] * 10000,
    'cholesterol' : [1,  2,  2, 1, 1, 1, 1, 1, 1, 1] * 10000,
    'smoke' :       [0,  0,  1, 1, 7, 8, 3, 4, 4, 2] * 10000},
     dtype = np.int64)
%timeit -n 10 df.assign(score=[score.get(tuple(v), 0) for v in df.values])
# 223 ms ± 9.28 ms per loop (mean ± std. dev. of 7 runs, 10 loops each)
%%timeit -n 10 
df.assign(score=[score.get(t, 0) for t in zip(*map(df.get, df))])
# 76.8 ms ± 2.8 ms per loop (mean ± std. dev. of 7 runs, 10 loops each)
%%timeit -n 10
df.assign(score=[score.get(v, 0) for v in df.itertuples(index=False)])
# 113 ms ± 2.58 ms per loop (mean ± std. dev. of 7 runs, 10 loops each)
%timeit -n 10 df.assign(score=df.apply(lambda x: score.get(tuple(x), 0), axis=1))
# 1.84 s ± 77.3 ms per loop (mean ± std. dev. of 7 runs, 10 loops each)
%%timeit -n 10
(df
 .set_index(['gender', 'age', 'cholesterol', 'smoke'])
 .assign(score=pd.Series(score))
 .fillna(0, downcast='infer')
 .reset_index()
)
# 138 ms ± 11.5 ms per loop (mean ± std. dev. of 7 runs, 10 loops each)
%%timeit -n 10
s=pd.Series(score)
s.index.names=['gender','age','cholesterol','smoke']
df.merge(s.to_frame('score').reset_index(),how='left').fillna(0).astype(int)
# 24 ms ± 2.27 ms per loop (mean ± std. dev. of 7 runs, 10 loops each)
%%timeit -n 10
df.assign(score=pd.Series(zip(df.gender, df.age, df.cholesterol, df.smoke))
                .map(score)
                .fillna(0)
                .astype(int))
# 191 ms ± 7.54 ms per loop (mean ± std. dev. of 7 runs, 10 loops each)
%%timeit -n 10
df.assign(score=df[['gender', 'age', 'cholesterol', 'smoke']]
                .apply(tuple, axis=1)
                .map(score)
                .fillna(0))
# 1.95 s ± 134 ms per loop (mean ± std. dev. of 7 runs, 10 loops each)
               
              
MultiIIndex。代替:df['score'] =df.set_index(['gender', 'age', 'cholesterol', 'smoke']).index.map(score).fillna(0).to_numpy()。